Archive for the Advanced Bioscience Resources (ABR) Category

Human-animal hybrid research combine to make Chimeras

Posted in Advanced Bioscience Resources (ABR), Animal Human Hybrid, Chimeras, fetal research, Fetal Stem Cell, Fetal Tissue with tags , , , , , , , , , , , , , , on September 7, 2018 by saynsumthn

Chimeras become a reality in disturbing new human-animal hybrid research

chimeras

Recently, scientists have made breakthroughs in the creation of human-animal hybrids known as chimeras(ky-MEER’-ehz), or a mix of human cells with an animal host. Nature.com explained, “To create chimeras, scientists generally inject pluripotent stem cells — which can become any type of organ — from one species into the early embryo of a second species.”

According to Science Alert, the term comes from “a legend in Greek mythology, describing a monster which was often depicted as a lion with a goat’s head sticking from the side of its neck, and a snake for a tail.”  A 2011 report from UK’s Academy of Medical Sciences notes that “human cells used to create chimeras can be taken with appropriate consent directly from early embryos (e.g. surplus from IVF treatments), aborted fetuses, or a live-born person (e.g. human liver cells, or a cancer biopsy) or from cultured human cell lines.”

Recently, Live Action News reported on how the FDA is contracting with Advanced Bioscience Resources to obtain fetal parts for experiments involving “humanized mice”. The contract states, “ABR is the only company that can provide the human fetal tissue needed to continue the ongoing research being led by the FDA. Fresh human tissues are required for implantation into severely immune-compromised mice to create chimeric animals that have a human immune system.”

Image: FDA Chimeric fetal tissue research

FDA Chimeric fetal tissue research

Live Action News consistently reports on the ethics of using aborted fetal parts for ghoulish experiments:

  • Videos from the Center for Medical Progress showed Planned Parenthood staffers haggling over the price of aborted baby body parts.
  • In the 1970s, aborted babies were being used for medical research funded by taxpayers at the EPA.
  • Experiments on aborted children date back to the 1930’s, including a number of experiments on living abortion survivors.
  • The National Research Act established the National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research, was chaired by Kenneth John Ryan, MD, who taught abortions.
  • Taxpayers have funded millions of dollars for human fetal tissue experiments for years through the National Institutes of Health (NIH), estimated to spend $103 million in FY2018 and $95 million in FY2019. It is unclear which of those studies include more ethical sources of tissue other than tissue from aborted fetuses.
Image: Human fetal research NIH estimates updated

Human fetal research NIH estimates updated

In 2016, NIH announced plans to rescind their moratorium forbidding federal funding of human/animal chimera embryo research. Alan Moy, M.D., CEO of Cellular Engineering Technologies and scientific director of the John Paul II Medical Research Institute, opposes the mixing of species.

Image: Objection to animal human chimera research

Objection to animal human chimera research

And, although it is unclear whether the controversial research uses human adult or embryonic tissue or cell lines, the United States Conference of Catholic Bishops objected to the “problem of exploiting human embryos as cell factories for research”.

NPR report also expressed ethical concerns. “One issue is that scientists might inadvertently create animals that have partly human brains, endowing them with some semblance of human consciousness or human thinking abilities,” the report read. “Another is that they could develop into animals with human sperm and eggs and breed, producing human embryos or fetuses inside animals or hybrid creatures.”

George DaleyDirector of Stem Cell Transplantation at Samuel E. Lux Children’s Hospital Boston, who presented at a 2015 NIH workshop on “animals containing human cells,” argued that, “Humanized mice have been essential for cancer research.”

Image: Humanized Mice Chimeras

Humanized Mice Chimeras

But Daley also admitted that even scientists had concerns about “the chimerizing of human cells with non-human primates over mice.” “[W]hat is the plausibility, with which a human cell would fundamentally change the nature of the animal host?” he asked.

Image: NIH Workshop concerns over chimerizing embryos

David Resnik from the Netherlands Institute of Health Sciences (NIHES) (6:06:16) pointed out that the “potential to humanize an animal’s brain” may cause the public to become uncomfortable, because “science moves fast… the specter of an intelligent mouse being stuck in a laboratory somewhere screaming ‘I want to get out’ can be very troubling to people… ”

“The public can change it’s mind just like that as we saw; the videos of… the abortion clinics… can have a tremendous impact on the public… “

In a January 2017 paper published in the journal Cell, scientists at the Salk Institute reported a breakthrough in “generating human cells and tissues in early-stage pig and cattle embryos” where they “[S]uccessfully implanted sows with those embryos”. Nature detailed how scientists “allowed the pig–human chimaeras to develop for three to four weeks before destroying them, according to ethics regulations”.

Image: Human Pig Chimeras

In 2011, media in the UK blew the lid on a secret program that created 150 human-animal hybrid embryos in British laboratories. According to a report in the Daily Mail, which explained, “This legalised the creation of a variety of hybrids, including an animal egg fertilised by a human sperm; ‘cybrids’, in which a human nucleus is implanted into an animal cell; and ‘chimeras’, in which human cells are mixed with animal embryos.”

In 2018, National Geographic reported the second successful human-animal hybrids: sheep embryos that are are 0.01-percent human by cell count.

Image: Human-pig Chimera

In 2016, Congressman Chris Smith introduced legislation to prohibit human/animal chimeras. The bill has essentially gone nowhere. In 2017, pro-life leaders asked the secretary of HHS for NIH to “withdraw the proposed changes to NIH guidelines which would allow funding for research which attempts to create human-animal chimeras… ”

To date, that has not happened.

$1 million to abortion clinics and Planned Parenthood for aborted fetal tissue from ABR

Posted in Aborted Baby Body Parts, Advanced Bioscience Resources (ABR), Center for Medical Progress, Chimeras, FDA, fetal research, Fetal Tissue, Planned Parenthood sells aborted baby parts with tags , , , , , , , , on September 6, 2018 by saynsumthn

Planned Parenthood got over $300,000 in 6 years from one fetal tissue harvester

Planned Parenthood

Live Action News recently reported about how the FDA is contracting with Advanced Bioscience Resources (ABR) to obtain “fresh human tissues” — aborted fetal body parts — “for implantation into severely immune-compromised mice to create chimeric animals that have a human immune system.” ABR’s history with fetal tissue research goes back years. According to the Center for Medical Progress, ABR is “the largest and oldest fetal tissue seller in the U.S.” It was founded in 1989, and is the primary supplier of fetal tissue for the U.S. government. And it has paid numerous abortion facilities a great deal of money for this tissue — including a number of Planned Parenthood centers.

The stunning graphic below from the House Select Investigative Panel report summarizes known ABR payments to various Planned Parenthood facilities for fetal tissue — totaling more than $350,000 over the course of six years, from 2010 to 2015:

Image: ABR 2015 Fetal Sales to Top 5 Customers Product and Totals (Image credit: Congressional Investigation)

ABR 2015 Fetal Sales to Top 5 Customers Product and Totals (Image credit: Congressional Investigation)

According to a 2015 report from Politico:

The Food and Drug Administration has also paid about $73,000 to the company since 2009… mostly for liver and thymus tissue that are used largely to develop a human-like immune system in mice…. The NIH, with a $30 billion budget for research nationwide, funded about $76 million in dozens of fetal tissue projects in 2014.

Image: FDA Chimeric fetal tissue research

FDA Chimeric fetal tissue research

The FDA has a dozen contracts with ABR for various items, including lab equipment and supplies, according to the General Services Administration’s Federal Procurement Data SystemOnline records at the National Institutes of Health (NIH) indicate ABR is regularly granted federal dollars for various projects.

READ: FDA buys ‘fresh’ aborted body parts from company referred for criminal charges

The 2015 Congressional investigation regarding the illegal sale of fetal body parts, following undercover videos released by CMP, led to a report. In this report, quoted below, it was revealed that ABR had been contracting with universities and abortion facilities for years:

  • Before [founder and CEO Cate Dyer] began StemExpress, she worked for Advanced Bioscience Resources, Inc. (ABR)
  • The University of Minnesota (UM)… obtains fetal tissue from procurement companies—in this case, Advanced Bioscience Resources (ABR) and StemExpress—in addition to an area clinic.
  • The University of Wisconsin, School of Medicine and Public Health (UW SMPH)… more recently obtained fetal tissue for research from the Albert Einstein College of Medicine, UW, and ABR.
  • Colorado State University (CSU)… receives a significant amount in federal grants and obtains much of its fetal tissue from ABR and StemExpress. Between 2010 and 2015, CSU received seven NIH grants to support their projects using fetal tissue, at a taxpayer expense of $3.5 million.
  • According to productions made by 25 clinics from which ABR has received fetal tissue, ABR paid them a total of $1,002,147 from 2010 to 2015…. The chart below shows ABR facility fee payments from 2010 through 2015 to the abortion clinics from which it obtained fetal tissue:
Image: ABRs abortion clinic facility fees 2010 to 2015 (Image credit” Select Panel investigation of fetal tissue)

ABRs abortion clinic facility fees 2010 to 2015 (Image credit” Select Panel investigation of fetal tissue)

The panel then detailed ABR’s 2015 fetal parts sales to its top five customers:

Image: ABR 2015 Fetal Sales to Top 5 Customers Product and Totals (Image credit: Congressional Investigation)

ABR 2015 Fetal Sales to Top 5 Customers Product and Totals (Image credit: Congressional Investigation)

In a letter from Rep. Marsha Blackburn to the then-District Attorney of Riverside, California, the Congresswoman detailed ABR’s relationship with Planned Parenthood:

Image: ABRs interactions with Planned Parenthood fetal tissue

ABRs interactions with Planned Parenthood fetal tissue (Image credit: Letter from Rep. Marsha Blackburn)

In 2016, Houston attorney Briscoe Cain claimed he found evidence of four Texas medical schools purchasing fetal tissue from ABR. Invoices from to one of the schools, given to KFOX14 Investigates and reported by CBS4, show the school paid at least $4,000-$5,000 for fetal parts including livers, spleens and thymuses.

Image: ABR invoices for fetal tissue to Texas Universities

ABR invoices for fetal tissue to Texas Universities

Image: ABR invoices for fetal parts to Texas Universities

ABR invoices for fetal parts to Texas Universities

“The research being done is humanized mice. Scientists inject the mouse with fetal tissue so the mouse is genetically altered to accept the graphing of human tissue,” Cain said at the time.

In 2011, the University of Minnesota contracted with ABR for “human fetal pancreas tissue” between 16-24 weeks.

Image: ABR contract with U of Minnesota for fetal tissue 2011

ABR contract with U of Minnesota for fetal tissue 2011

In 2000, the Government Accountability Office (GAO) was tasked to study “the involvement of federal agencies under the jurisdiction of the Senate Committee on Appropriations, Subcommittee on Labor, Health and Human Services, and Education in the acquisition of human fetal tissue for biomedical research.” The Department of Health and Human Services (HHS) told GAO that “NIH is the only federal agency under the Labor, HHS, and Education Subcommittee’s jurisdiction that sponsors research using human fetal tissue.” But Live Action previously showed that the EPA used aborted fetal tissue for research in the 1970’s.

According to that report, NIH sponsored three central human fetal tissue supply organizations:

  • The Birth Defects Laboratory at the University of Washington, which distributed 2,869 human fetal tissue samples and collected $52,035 in fees directly from researchers in fiscal year 1999.
  • The Brain and Tissue Banks for Developmental Disorders at the University of Maryland and the University of Miami School of Medicine/Children’s Hospital of Orange County, primarily to serve as suppliers of human nonfetal tissue…. The University of Maryland Bank provided 195 human fetal tissue samples to investigators in fiscal year 1999, and the University of Miami Bank provided approximately 40 samples between March 1 and August 31, 1999.

GAO states that researchers also obtained human fetal tissue from private organizations that did not directly receive federal funds, including ABR.